Read the Cards Below for Study and Corresponding References
Therapy for Dementia: A Systematic Review of Pre-Clinical and Clinical Studies, Farzad Salehpour, All of the included studies reported positive results.
Photobiomodulation promotes hair regeneration in injured skin. Yuehou Zhang, The application of photobiomodulation (PBM) in regenerative medicine has expanded to the treatment of alopecia caused by various reasons. We now have proof that we understand how PBM helps to stimulate hair growth.
Photobiomodulation Response From 660 nm is Different and More Durable, Christine Fuchs, These findings demonstrate that 660 nm is a different physiological pathway than 980 nm and provides a more durable and effective healing response than from 980 nm.
Irradiation of the Stellate Ganglion reduced VAS scores and increased local temp due to an increase regional blood flow by a reduction in vascular tone.
Meta-analysis demonstrated that low-level laser improved hand grip, pain, and sensory nerve function.
LLLT can inhibit some bacteria and viruses.
Laser improves osteoblastic formation, bone strength in fractures, implant stability, and can improve osteonecrosis of the jaw.
INCREASES: Mitochondria and ATP production, Cytochrome oxidase and singlet oxygen, tissue regeneration genes and motor proteins, RNA DNA synthesis, growth factors, cell metabolism, angiogenesis, and mitosis.
LLLT can inhibit some bacteria and viruses.
Cell proliferation, cell division, cell maturation, secretion of growth factors, wound healing, collagen production, wound strength, wound closer, fibroblasts, myofibroblasts, chondrocytes, epithelialization, skin circulation, oxygen supply, activity satellite cell cultures (stem cells).
LLLT passing through the skull with an 808 nm wavelength laser penetrated approximately 40 mm (1.6 inches)
808 nm laser produced 1 mW/cm2 was achieved at 3.4 cm (1.36 inches), but for 980 nm achieved only 2.2 cm (less than 1 inch). It was determined that 808 nm of light penetrates as much as 54% deeper than 980 nm light.
Animal study; 810-nm laser was almost as good as cortisone at reducing swelling.
Higher doses showed most benefit.
Laser therapy reduced joint swelling and correlated with decreased serum prostaglandins.
Laser plus cortisone more effective than cortisone by itself.
Lower Doses Stimulate, Higher Doses Inhibit. Using 14X the dose inhibited tissue repair.
A significant improvement in laser therapy compared to the control group. The treatment group experienced significantly less pain and significantly improved disability scores. Range of motion in the treatment group was better than placebo.
Meta-analysis of studies covered in this review found an overall
improvement in hair regrowth, thickness, and patient satisfaction following LLLT.
Most laser radiation was absorbed within the first 1mm of skin.
Lower Doses Stimulate, Higher Doses Inhibit
Cumulative effect of lower doses (2.5 or 5 J/cm(2)) determines the stimulatory effect, while multiple exposures at higher doses (16 J/cm(2)) result in an inhibitory effect with more damage.
INCREASE MOUTH OPENING, DECREASED MUSCULAR PAIN, DECREASED EATING DIFFICULTY, AND DECREASED TENDER POINTS
DECREASES: Inflammatory mediators, Cytokine receptors, Inflammatory proteins, Genes that code for inflammation, Proapoptotic proteins.
The best organization of collagen were shown by the lower densities. All wavelengths and fluences used in this study were efficient at accelerating the healing process, with lower densities better than higher, hotter densities.
Harvard research shows that LLLT is a promising treatment for many types of brain disorders.
The best organization of collagen were shown by the lower densities. All wavelengths and fluences used in this study were efficient at accelerating the healing process, with lower densities better than higher, hotter densities.
Meta-analysis of 533 studies showed can increase in muscle mass after training, and a decrease in inflammation and oxidative stress in muscle biopsies.
Laser Helps TB Treatment: Laser plus medication better than medication alone for tuberculosis.
Improves oxygen production, promoting cellular survival, Increased Cytochrome c oxidase—terminal enzyme of the electron transport chain and a strong photoacceptor and other mitochondral enzymes.
LLLT accelerates peripheral nerve regeneration.
LLLT improves chronic neck pain and function.
Controlled trial showed regeneration of sciatic nerve and myelination in rats.
LLLT reduces inflammation and improves function, in some cases superior to NSAIDs.
LLLT reduces pain in chemotherapy induced oral mucositis.
LLLT helps patients with diabetic peripheral neuropathy.
LLL improves nerve function with Parkinson’s.
Lasers and LED’s of Optimal Wavelength Penetrate up to 23 cm (4 studies).
Applied directly to SP of porcine subjects; 6% of photons reached cord and increased CGRP/mRNA.
INCREASES: cell proliferation, cell division, cell maturation, secretion of growth factors, wound healing, collagen production, wound strength, wound closer, fibroblasts, myofibroblasts, chondrocytes, epithelialization, skin circulation, oxygen supply, activity satellite cell cultures (stem cells).
DECREASES: Prostaglandin E2, substance P, cyclooxygenase 2 (Cox 2), muscle tension.
LLL applied to skull decreased depression and anxiety.
Decrease of pain and anti-inflammatory effects; confirmed by thermographic examination.
Animal Study; Neurological deficits improved.
Laser applied to skull improves brain following stroke.
Laser improves the function of the thyroid based on lab values with chronic autoimmune thyroiditis.
Acute tendinitis had the best response.